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  • Title: An aerosol challenge model of Bordetella pertussis infection as a potential bioassay for acellular pertussis vaccines.
    Author: Xing DK, Das RG, Williams L, Canthaboo C, Tremmil J, Corbel MJ.
    Journal: Vaccine; 1999 Feb 12; 17(6):565-76. PubMed ID: 10075163.
    Abstract:
    Whole cell and five different types of acellular pertussis vaccine were assayed using a mouse aerosol challenge model which permitted delivery of a controlled, consistent dose of Bordetella pertussis to the lower respiratory tract. Using this system, the viable counts in the lungs of vaccinated mice were immunisation dose-dependent and allowed the protective capacity of different vaccine preparations to be distinguished. This model may thus provide the basis for a protection assay for pertussis vaccines. Comparison of acellular vaccines with a whole cell pertussis vaccine showed that the latter gave better active protection in mice but with a different dose-response relationship. Thus the two types of vaccine are not directly comparable in the same assay and require different reference standards. A pentavalent type acellular vaccine is suggested as a possible candidate standard for the acellular vaccine potency test. The results suggest that this aerosol challenge model has potential for use as a potency test for acellular pertussis vaccines.
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