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  • Title: Two new pyridine monoterpene alkaloids by chemical conversion of a commercial extract of harpagophytum procumbens.
    Author: Baghdikian B, Ollivier E, Faure R, Debrauwer L, Rathelot P, Balansard G.
    Journal: J Nat Prod; 1999 Feb; 62(2):211-3. PubMed ID: 10075743.
    Abstract:
    The treatment of harpagide (1), harpagoside (2), or 8-O-p-coumaroylharpagide (3), the main iridoids of Harpagophytum procumbens and Harpagophytum zeyheri, with NH3 and HCl led to aucubinine B(4), a pyridine monoterpene alkaloid (PMTA). A similar procedure applied to a commercial extract of H. procumbens yielded 4 and two new PMTAs named beatrine A (5) and beatrine B (6). The structures of these new PMTAs were established using ESIMS and 2D NMR. Their semisynthesis was analyzed in terms of reaction mechanisms.
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