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  • Title: Spinal integration of antidromic mediated cutaneous vasodilation during dorsal spinal cord stimulation in the rat.
    Author: Barron KW, Croom JE, Ray CA, Chandler MJ, Foreman RD.
    Journal: Neurosci Lett; 1999 Feb 05; 260(3):173-6. PubMed ID: 10076895.
    Abstract:
    The purpose of this study was to determine the involvement of supraspinal centers and spinal synaptic integration in cutaneous vasodilation mediated by dorsal spinal cord stimulation (DCS). Laser Doppler flowmetry was used to assess cutaneous blood flow changes in the rat hindpaw during DCS with a unipolar ball electrode placed at the L2-L3 spinal level. Results demonstrated that transecting the spinal cord at the T10 spinal segment did not alter the DCS response while T13 spinal transection abolished the DCS-induced vasodilation. Inhibition of synaptic activity with topical application of muscimol (0.2 mM) on the dorsal surface of the spinal cord markedly attenuated the DCS response. In conclusion DCS-induced vasodilation involved synaptic integration but did not require input from rostral spinal sites or supraspinal areas.
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