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  • Title: Decreased Na,K-ATPase activity by glycation at the catalytic center.
    Author: Katori T, Bannai C, Hayashi Y, Yamashita K.
    Journal: Horm Metab Res; 1999 Jan; 31(1):5-7. PubMed ID: 10077341.
    Abstract:
    The in vitro activity of Na,K-ATPase isolated from outer medulla of dog kidney was decreased in a dose- and time-dependent manner by interaction with 100 mM glucose 6-phosphate (G6P) during the first 8 h. In the subsequent 16 h no change in activity was observed. On the other hand, Amadori-products of the enzyme increased in a dose- and time-dependent manner by glycation up to 100 mM G6P during 24 h. The presence of 5 mM ATP in glycation experiments protected the enzyme activity but did not inhibit the formation of Amadori-products. These results were consistent with inhibition of the Na,K-ATPase activity by glycation of the amino groups located in the catalytic center of the molecule.
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