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  • Title: Effects of prostaglandins in canine endotoxin shock.
    Author: Shatney CH, Lillehei RC.
    Journal: Acta Biol Med Ger; 1976; 35(8-9):1141-9. PubMed ID: 1007762.
    Abstract:
    Endotoxin shock was produced in healthy, adult mongrel dogs by the intravenous injection of 1.5 mg/kg of E. coli endotoxin. The 24 hour survival of untreated animals was 34% and was not enhanced by volume replacement with low molecular weight dextran. Treatment with dextran and prostaglandin A1 or E1, although effecting significant hemodynamic improvements, did not increase survival.
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