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  • Title: [Bickerstaff's brainstem encephalitis with one-and-a-half syndrome].
    Author: Koyama S, Kuroda K, Aizawa H, Kikuchi K, Kusunoki S.
    Journal: Rinsho Shinkeigaku; 1998 Sep; 38(9):849-52. PubMed ID: 10078040.
    Abstract:
    We presented a case of Bickerstaff's brainstem encephalitis. A 50-year-old woman developed semicoma, external ophthalmoplegia, hyporeflexia, extensor plantar responses. A high titer of anti-GQ1b IgG antibody was detected in her acute phase serum. Auditory brainstem response suggested the presence of brainstem lesion. Although MRI and CSF showed no abnormality, one-and-a-half syndrome was observed during the clinical course, suggesting involvement of the pontine tegmentum. She received steroid pulse-therapy and symptoms disappeared completely. Our case suggested that anti-GQ1b IgG antibody might relate to the pathogenesis of intramedullary as well as extramedullary lesions.
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