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  • Title: Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.
    Author: Ide N, Hata Y, Deguchi M, Hirao K, Yao I, Takai Y.
    Journal: Biochem Biophys Res Commun; 1999 Mar 24; 256(3):456-61. PubMed ID: 10080919.
    Abstract:
    Synaptic scaffolding molecule (S-SCAM) is a multiple PDZ domain-containing protein, which interacts with neuroligin, a cell adhesion molecule, and the NMDA receptor. In this study, we searched for S-SCAM-interacting proteins and obtained a neuralplakophilin-related armadillo-repeat protein (NPRAP)/delta-catenin. NPRAP/delta-catenin bound to the last PDZ domain of S-SCAM via its carboxyl-terminus in three different cell-free assay systems, was coimmunoprecipitated with S-SCAM from rat crude synaptosomes, and was localized at the excitatory synapses in rat hippocampal neurons. NPRAP/delta-catenin may be implicated in the molecular organization of synaptic junctions through the interaction with S-SCAM.
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