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  • Title: Macrophages in host defense against Histoplasma capsulatum.
    Author: Newman SL.
    Journal: Trends Microbiol; 1999 Feb; 7(2):67-71. PubMed ID: 10081083.
    Abstract:
    Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.
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