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  • Title: Current studies on a working model of CaM kinase II in hippocampal long-term potentiation and memory.
    Author: Fukunaga K, Miyamoto E.
    Journal: Jpn J Pharmacol; 1999 Jan; 79(1):7-15. PubMed ID: 10082312.
    Abstract:
    There have been recent advances in understanding the molecular basis of the long-term potentiation (LTP) of synaptic transmission in the hippocampus. This review documents current views on mechanisms underlying LTP induction, from activation of the NMDA receptor to stimulation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). We will focus in particular on recent findings of how CaM kinase II encodes the frequency of synaptic usage and serves as a molecular memory switch at the synapse. Furthermore, a role for CaM kinase II in spatial learning and memory is demonstrated by recent studies using transgenic mice.
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