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  • Title: Olanzapine treatment after clozapine-induced granulocytopenia in 3 patients.
    Author: Swartz JR, Ananth J, Smith MW, Burgoyne KS, Gadasally R, Arai Y.
    Journal: J Clin Psychiatry; 1999 Feb; 60(2):119-21. PubMed ID: 10084639.
    Abstract:
    BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem. CASE REPORTS: We report 3 patients with chronic schizophrenia who had previously stopped clozapine due to hematologic side effects. The patients evidenced improvement with olanzapine that equated to 16- to 31-point decreases in rating scale scores during 1-year follow-up without any hematologic abnormalities. CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.
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