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  • Title: [Fever due to antithyroid agents].
    Author: Shamelian SO, Nortier JW.
    Journal: Ned Tijdschr Geneeskd; 1999 Jan 30; 143(5):225-8. PubMed ID: 10086149.
    Abstract:
    Three patients, females aged 62, 67 and 32 years, were presented with fever and sore throat and had severe agranulocytosis (granulocyte count < 100/microliter). All had Graves' disease and were being treated with thiamazole 30 mg once a day. Thiamazole was discontinued and treatment with antibiotics initiated. None of the patients received granulocyte-colony stimulating factor (G-CSF). The mean recovery time of granulocytes was 9 days and there were no fatalities. Patients who receive antithyroid agents should be warned against the serious and potentially lethal side effect of agranulocytosis.
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