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  • Title: Successful treatment of a non-haemophilic patient with inhibitor to factor VIII by double-filtration plasmapheresis.
    Author: Sunagawa T, Uezu Y, Kadena K, Tokuyama K, Kinjo F, Saito A.
    Journal: Br J Haematol; 1999 Mar; 104(3):465-7. PubMed ID: 10086780.
    Abstract:
    Factor VIII (FVIII) inhibitors appear in 3-20% of haemophilia A patients after injection of FVIII concentrates. However, autoantibodies to FVIII are also reported in non-haemophiliacs. In these patients FVIII inhibitor disappears spontaneously or diminishes in response to immunosuppressive therapy. However, a few patients show resistance to immunosuppressive therapy. We describe a non-haemophilic elderly patient with acquired FVIII inhibitor who failed to respond to prednisolone. He was treated with double-filtration plasmapheresis (DFPP) which resulted in a very rapid reduction in inhibitor levels and resolution of symptoms.
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