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  • Title: The expression of cyclooxygenase-2 in human umbilical vein endothelial cell culture from preeclampsia.
    Author: Akarasereenont P, Techatraisak K, Chotewuttakorn S, Thaworn A.
    Journal: J Med Assoc Thai; 1999 Feb; 82(2):167-72. PubMed ID: 10087724.
    Abstract:
    We have shown the HUVEC from normal pregnancy contained COX-1 protein but not COX-2 protein and released 6-keto-PGF1 alpha 277 +/- 5 ng/ml (for 24 h). In contrast, HUVEC from preeclampsia contained both COX-1 and COX-2 protein and released significantly lesser amounts of 6-keto-PGF1 alpha (159 +/- 8 ng/ml for 24 h; p < 0.05). Thus, COX-2 is expressed in HUVEC from preeclampsia but not in normal pregnancy and affects the release of prostacyclin suggesting the involvement of COX-2 in the pathogenesis of preeclampsia. The development of selective inhibitors of COX-2 may have a potential role in prevention and treatment of preeclampsia.
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