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  • Title: [Randomized trial of two administration schedule of bonephos (Clodronate) in patients with painful bone metastasis].
    Author: Moiseenko VM, Blinov NN, Semiglazov VV, Konstantinova MM, Trishkina EA.
    Journal: Vopr Onkol; 1998; 44(6):725-8. PubMed ID: 10087976.
    Abstract:
    A randomized study of two intravenous schedules of Clodronate showed that a single 4-hour infusion of 1500 mg Clodronate proved significantly more effective than the traditional 2 hours infusion of 300 mg during 5 days. The regimen may prove preferable in therapy of patients with painful bone metastases.
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