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  • Title: On the relationship of OSW-1 to the cephalostatins.
    Author: Guo C, LaCour TG, Fuchs PL.
    Journal: Bioorg Med Chem Lett; 1999 Feb 08; 9(3):419-24. PubMed ID: 10091695.
    Abstract:
    Antineoplastic bis-steroidal (cephalostatin-type) analogues of the saponin OSW-1 were produced from a dihydroaglycone of OSW-1. The key aglycone 6H was obtained from 5alpha-androstan-3beta-ol-17-one in 8 steps (38% yield). The SAR of the aglycones, intermediates, and hybrid analogues provide insights regarding the proposed common role of C22-oxocarbenium ions in the bioactivity of both OSW-1 and cephalostatins.
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