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  • Title: [Criteria selection for the preliminary evaluation of the efficacy of antihypoxic agents].
    Author: Lunets EF, Tatarinov BA, Petrovskiĭ CG.
    Journal: Biofizika; 1976 Nov; 21(6):1054-8. PubMed ID: 1009197.
    Abstract:
    Mathematical description is suggested of oxygen consumption by mitochondria suspension in the presence of orto-benzoquinone derivatives. An analysis of the equations obtained, in vivo conditions taken into account, has shown that the efficiency of hydrogen consumption is mainly determined by the constant value of oxidation rate of quinone reduced form, poorely depends on the substrate concentration and activity of quinone-reducing enzymes. The constant value of oxidation rate may serve as a criterion of directed synthesis of antihypoxants.
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