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  • Title: Synergistic inhibition of carboxypeptidase A by zinc ion and imidazole.
    Author: Mock WL, Wang L.
    Journal: Biochem Biophys Res Commun; 1999 Apr 02; 257(1):239-43. PubMed ID: 10092540.
    Abstract:
    Zinc ion in solution yields a 560-fold enhancement in the kinetic inhibition of carboxypeptidase A by the simple heterocycle imidazole, behavior attributed to formation of a ternary complex of the three species. However, the effect is partially negated by formation of less-inhibitory Zn2+(C3H4N2)2-4 coordination complexes, providing for the enzyme an anomalous profile of catalytic rate versus imidazole concentration.
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