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  • Title: Artificial insemination (A.I.H.) for sperm antibodies and oligozoospermia.
    Author: Usherwood MM, Halim A, Evans PR.
    Journal: Br J Urol; 1976 Dec; 48(6):499-503. PubMed ID: 1009335.
    Abstract:
    Artificial insemination using husband's semen (A.I.H.) was carried out in 74 couples in most of whom the men had low sperm densities and/or a reduced sperm motility. There were 19 pregnancies (24%). The problems encountered and the reasons for failure are discussed. A method of artificial insemination with couples suffering a variety of infertile conditions (retrograde ejaculation, low sperm density, low sperm motility, sperm antibodies, and cervical ''hostility'') is presented. 19 pregnancies from 74 couples were achieved in 2 years. Where appropriate, ovulation was induced in women with clomiphene citrate. Men with low sperm densities were given clomiphene citrate 50 mg daily and/or fluoxymesterone 5 mg daily. After a good response to treatment was noted (a sperm count of more than 10 X 10(6)/ml, when motility was more than 30%, if antibodies were demonstrated in either partner, and if cervical ''hostility'' had been demonstrated), AIH was offered. Couples were asked to abstain from intercourse for 1 week before the husband produced a fresh specimen of semen on the day of insemination. Sperm samples were washed and centrifuged twice. The woman was positioned in a cystoscopic chair and the semen was injected slowly. The patient rested after insemination for about 15 minutes. 6 inseminations were performed in each case before the situation was reviewed. Failures were due to tubal obstruction which was undiagnosed, endocrine deficiencies, and cervical ''hostility.''
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