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  • Title: Effects of niacin therapy that simulate neoplasia: hepatic steatosis with concurrent hepatic dysfunction.
    Author: Kristensen T, Olcott EW.
    Journal: J Comput Assist Tomogr; 1999; 23(2):314-7. PubMed ID: 10096345.
    Abstract:
    Niacin, a widely used antihyperlipidemic agent, can produce hepatic steatosis and clinical hepatic abnormalities that together simulate the presentation of hepatobiliary neoplasia. We describe a patient initially suspected of having hepatobiliary neoplasia for whom imaging studies played a pivotal role in reaching the correct diagnosis of niacin-induced hepatotoxicity. Radiologists should become knowledgeable of these niacin-related effects, add niacin effects to the differential diagnosis of hepatic steatosis, and understand the value of correlative imaging in distinguishing these effects from hepatobiliary neoplasia.
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