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  • Title: Tamm-Horsfall protein excretion and its relation to citrate in urine of stone-forming patients.
    Author: Ganter K, Bongartz D, Hesse A.
    Journal: Urology; 1999 Mar; 53(3):492-5. PubMed ID: 10096372.
    Abstract:
    OBJECTIVES: To evaluate the relation of Tamm-Horsfall protein (THP) and citrate, both potent actors in the urinary stone forming process. METHODS: Quantitative determination of THP in calcium oxalate (CaOx) stone-forming patients and healthy subjects was carried out according to the enzyme-linked immunosorbent assay method. RESULTS: THP excretion in 24-hour urine samples of CaOx stone-forming patients was significantly reduced compared with healthy subjects. A significant correlation exists between the concentration of THP and citrate in the stone-forming group, as well as in the group of healthy subjects, and for the 24-hour excretion, this correlation persists in the group of CaOx stone-forming patients. CONCLUSIONS: Decreased THP and citrate excretions were found in CaOx stone-forming patients. They indicate a tubular dysfunction of the distal section.
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