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  • Title: [Lipid mobilization in obesity without carbohydrate intolerance. 2. Caffeine-stimulated lipolysis].
    Author: Ratzmann KP, Riemer D, Männchen E, Paul I.
    Journal: Endokrinologie; 1976; 68(3):319-26. PubMed ID: 1009910.
    Abstract:
    The lipolysis induced by i.v. injection of caffeine (3 mg/kg body weight) has been investigated in 11 normal subjects and 18 obese patients with normal 50 g oral glucose tolerance test and normal thyroid-function. The pattern of blood-glucose and immunoreactive insulin (IRI) secretion were not influenced by caffeine in both groups. Both in the controls and obese group a significant response of FFA and glycerole were noted. In the obese group the caffeine-induced lipolysis was slightly higher as compared with controls. There are no differences in FFA-response between obese group and controls. The observations suggest that an impaired lipolysis is not a pathogenetic factor for development of obesity.
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