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  • Title: Further evidence of permanent behavioural changes in rats treated neonatally with neurodrugs.
    Author: Dörner G.
    Journal: Endokrinologie; 1976; 68(3):345-8. PubMed ID: 1009911.
    Abstract:
    Pargyline or reserpine treatment of male rats during the first two weeks of life resulted in significantly increased exploratory activity (sniffing) associated with a significantly decreased emotional reactivity (defecation rate) in adult life. These findings suggest that nonphysiological concentrations and/or turnover rates of neurotransmitters during brain differentiation apparently produced by neurodrugs can lead to permanent behavioural changes.
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