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  • Title: On the initiation of mammalian RNA polymerase at single-strand breaks in DNA.
    Author: Dreyer C, Hausen P.
    Journal: Eur J Biochem; 1976 Nov 01; 70(1):63-74. PubMed ID: 1009933.
    Abstract:
    Mammalian RNA polymerase B is able to initiate at single-strand breaks in the DNA template. A 3'-OH end at a nick is required for initiation whereas the 5'-end may be either -- OH or phosphate. The 3'-OH group does not function as a primer. An appreciable part of the newly synthesized RNA started at a nick remains associated with the DNA in hydrid form. Initiation of exogeneous RNA polymerase B on chromatin exhibits similar requirements.
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