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  • Title: The immunology of preeclampsia.
    Author: Dekker GA, Sibai BM.
    Journal: Semin Perinatol; 1999 Feb; 23(1):24-33. PubMed ID: 10102168.
    Abstract:
    The immune maladaptation hypothesis of preeclampsia is concordant with cytokine-mediated oxidative stress, chronology of endothelial activation, lipid changes, adverse effect of changing partners, and the protective effect of sperm exposure. Genetic factors may involve underlying hereditary thrombophilic disorders and hyperhomocysteinemia, essential hypertension and/or obesity, or control of the Th1/Th2 balance and thus affect the maternal response against fetal antigens. Placental ischemia and increased syncytiotrophoblast deportation are probably end-stage disease phenomena.
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