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  • Title: [Coagulologic characteristics of different stages of chronic circulatory insufficiency in atherosclerotic cardiosclerosis].
    Author: Gritsiuk AI, Mamedov MB, Shchigel'skiĭ VI.
    Journal: Kardiologiia; 1976 Dec; 16(12):25-32. PubMed ID: 1011478.
    Abstract:
    A total of 168 patients with atherosclerotic cardiosclerosis and different stages of chronic circulatory insufficiency were subjected to an examination of the state of their blood coagulation (thromboelasto- and coagulogramme) and fibrinolytic systems (indices of the general fibrinolytic activity of the blood, some components of fibrinolysis). In cases of circulatory insufficiency at its early stages (especially IIA) distinct signs of blood hypercoagulation were found to develop at the expense of an elevation of the level of fibrinogen A and B fibrinstabilizing factor, a reduction of the content of antithrombins and heparin, as well as signs of fibrinolysis inhibition at the expense of an increase of the level of plasminogen and antiplasmins activation inhibitors, fast acting including. During Stages IIB and III of circulatory insufficiency the signs of hypercoagulation of the blood and fibrinolysis inhibition are noted to decrease, although they do not disappear completely.
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