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  • Title: [Mechanism of regulation of themitochondrial creatine phosphokinase reaction by magnewium ions].
    Author: Saks VA, Gukovskiĭ DE, Lipina NV, Smirnov VN, Chazov EI.
    Journal: Kardiologiia; 1976 Sep; 16(9):72-9. PubMed ID: 1011532.
    Abstract:
    The method of mathematical modelling and kynetic analysis was used to study the mechanism of the regulatory effect of magnesium ions on the creatinephosphokinase reaction in cardiac mitochondria. The regulatory effect of magnesium was shown to originate from the competition between ATP and ADP and the magnesium-complex-formation reaction, and the actual regulator proves to be MgADP. On the basis of the data obtained it is postulated that creatinephosphokinase in cardiac mitochondria is functionally connected with ATP-ADP-translocase. The obtained data permit to believe that the mitochondrial cratinephosphokinase is one of the key links in the process of energy transport in the cardiac cells.
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