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  • Title: [Demonstration of specific IgM antibody in cases of suspect congenital toxoplasmosis: interpretation of results (author's transl)].
    Author: Werner H, Schöning C, Neuhaus B, Maute I.
    Journal: Z Geburtshilfe Perinatol; 1976 Dec; 180(6):438-44. PubMed ID: 1014782.
    Abstract:
    From the aspect of laboratory Toxoplasmosis examination, a series of clinically and parasitologically confirmed cases of congenital Toxoplasmosis (CT) were selected. Serological findings (CFT, DT, IgM-IFAT) in infants and mothers were critically examined. The IgM titers in CT as a rule lay between 1:16 and 1:64, the highest recorded being 1:256. The serum IgM globulin levels showed no dependence on the high CFT titers. T recognize unspecific reactions amongst infants with positive IgM values, the serological testing of mothers was indispensable. It is also absolutely necessary with infants to repeatedly test serologically at intervals to clearly bring out the results of all the three serological reactions. The technical problems encountered for a definative diagnosis of CT and the clinical picture in the present critical examination are discussed.
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