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  • Title: Effect of chronic exposure to nitrogen dioxide on collagen fractions content in skin of guinea pigs.
    Author: Drózdz M, Kucharz E.
    Journal: Acta Biol Med Ger; 1976; 35(7):1023-5. PubMed ID: 1015159.
    Abstract:
    Guinea pigs were exposed to nitrogen dioxide in concentration of 2 mg/m3 (8 hrs. daily, 180 days). Control group inspired fresh air. Collagen fractions were estimated in skin and assayed as hydroxyproline concentration. An increase of total collagen content, due to on increase of salt-soluble collagen fraction was found in the skin of the exposed animals, while a simultaneous decrease of insoluble collagen content was observed.
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