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  • Title: [Role of the kidneys in the mechanism of erythrodieresis in hemolytic (phenylhydrazine) and acute posthemorrhagic anemia].
    Author: Novikov NM, Blium LI, Stagis AV.
    Journal: Biull Eksp Biol Med; 1976; 82(11):1311-3. PubMed ID: 1016705.
    Abstract:
    The degree of hemolysis was studied comparatively in intact and nephrectomized rats after the phenylhydrazine injection. In the nephrectomized animals hemolytic (phenylhydrazine) anemia was expressed by a lesser reduction of the total erythrocyte count, of the percentage of Cr51-labeled erythrocytes, and of the intensity of the reaction for hemosiderin in the organs and tissues. A lesser degree of erythrodieresis was found in the nephrectomized rats and after an acute unsubstituted blood loss. Blood perfusion through the kidney of anemic rats led to increase of the potassium concentration in the plasma perfusate, reduction of the electrophoretic mobility of erythrocytes, their resistance, hemolysis duration, and to decrease of albumin fractions with the mol wt of from 74 500 to 27 000 in the erythrocyte stroma.
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