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  • Title: The effect of withaferin A on human peripheral blood lymphocytes. An electron-microscope study.
    Author: Shohat B, Ben-Bassat M, Shaltiel A, Joshua H.
    Journal: Cancer Lett; 1976 Nov; 2(2):63-70. PubMed ID: 1016960.
    Abstract:
    Cultures of normal human peripheral blood lymphocytes stimulated by phytohaemagglutinin (PHA) were treated with withaferin A and examined by an electron microscope. The compound was found to affect the spindle microtubules of cells in metaphase. There were no intact pole-to-pole microtubules or pole-to-kinetochore microtubules found in the treated cells; the centrioles were located in the center. Furthermore, cells at interphase were also affected, the membrane system of the cells being damaged.
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