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  • Title: Porous implants for knee joint meniscus reconstruction: a preliminary study on the role of pore sizes in ingrowth and differentiation of fibrocartilage.
    Author: Klompmaker J, Jansen HW, Veth RP, Nielsen HK, de Groot JH, Pennings AJ.
    Journal: Clin Mater; 1993; 14(1):1-11. PubMed ID: 10171996.
    Abstract:
    Implants with four different macropore sizes were implanted in the meniscus of 29 rabbits for assessment of ingrowth and differentiation of fibrocartilage. Implant macropores were 50-90, 90-150, 150-250 and 250-500 mum, the vol.% macropores was 48-55 and total pore volume 84-86 vol.%. Ingrowth was optimal in the two large pore implants whereas the small pore implants partially remained empty up to 1 year post-operative. Capsule formation and the foreign body reaction was severe for the small pore implants whereas this occurred to a lesser extent in the two large pore implants. Fibrocartilage formation, as assessed by morphology and antibody labelling for type I and type II collagen, was observed in a similar way in all implant types. It is concluded that for optimal ingrowth and incorporation of partial or total meniscal prosthesis, macropore sizes must be in the range of 150-500 mum.
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