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  • Title: Antimycotic activity in vitro and in vivo of a new hydrosoluble polyene antibiotic.
    Author: Strippoli V, Evangelista AM, Simonetti N.
    Journal: Farmaco Sci; 1976 Dec; 31(12):891-900. PubMed ID: 1017483.
    Abstract:
    The in vitro and in vivo activity of a new water soluble polyene antibiotic, anmed SPA-S-222, has been studied on numerous Candida and Cryptococcus species. The in vitro tests were carried out in comparison with nystatin and amphotericin B whose antimycotic properties are already well known. The inhibition of "germination" of various strains of Candida albicans was also investigated. The results show that SPA-S-222 has greater antimycotic activity than nystatin or amphotericin B. Tests on the protection afforded by SPA-S-222 in Swiss albino mice infected with C, albicans were satisfactory as regards both the total protective dose and the partial protective dose (P.D. 50%).
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