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  • Title: Cardiac electrical instability of the arrhythmogenic tissue substrate assessed by means of wavelet transform.
    Author: Popescu M, Laskaris N, Merloi A, Chiladakis I, Stathopoulos C, Manolis A, Cristea P, Bezerianos A.
    Journal: Stud Health Technol Inform; 1997; 43 Pt B():551-5. PubMed ID: 10179726.
    Abstract:
    The unstable activation wavefront from the tissue responsible for the production of ventricular tachycardia (VT) gives rise to beat-variable signals components that are eluded during the averaging step of high resolution ECG (HRECG). We used a mathematical model of small variations in a largely repetitive waveform to evaluate the beat-to-beat variance of the HRECG signal. The ability of the Morlet Wavelet Transform to discriminate the different factors responsible for the beat-variability (the alignment error and the beat-variable signal component) has been assessed on simulated signals. The performance evaluation on real ECG signals from normal subjects and patients with a documented history of ventricular tachycardia showed that the dynamics of the arrhythmogenic substrate as revealed by wavelet transform offers a significant improvement in ventricular tachycardia risk assessment.
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