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  • Title: An integrated model of sleep regulation.
    Author: Ruggiero C, Giacomini M, Schiavi G, Nobili L, Ferrillo F.
    Journal: Stud Health Technol Inform; 1997; 43 Pt B():581-5. PubMed ID: 10179732.
    Abstract:
    We present a new model of sleep regulation which integrates the two process model and the limit cycle reciprocal interaction model. In the two process model the interaction of a homeostatic process (S signal) and of a circadian process determines the timing of sleep and waking. In the limit cycle model, the NREM-REM sleep cycle is generated by the reciprocal interaction of two coupled cell population. The present model integrates the two considered models introducing the trigger REM-NREM generated by the REM-ON signal and activated when REM-ON overcomes the S signal.
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