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  • Title: Biodegradable osteosynthesis material for stabilization of midface fractures: experimental investigation in sheep.
    Author: Bähr W, Stricker A, Gutwald R, Wellens E.
    Journal: J Craniomaxillofac Surg; 1999 Feb; 27(1):51-7. PubMed ID: 10188128.
    Abstract:
    The most frequently tested biodegradable osteosynthesis materials have up to now largely consisted of poly-L-lactide (PLLA). The PLLA polymers appear to have sufficient mechanical strength for fracture treatment in the midface, but their degradation does not seem to be uniform enough to allow their clinical use. During the degradation process the disintegration products elicit a foreign body reaction due to non-uniform degradation rates. The foreign body reaction is sometimes combined with a fluctuant swelling at the implantation site. Implants injection-moulded from 90:10 PLLA/PGA (polyglycolic acid) have a more uniform degradation rate and seem to lead to a milder foreign body reaction. We bridged Le Fort I osteotomies in sheep using a system of injection-moulded PLLA/PGA 90:10 plates and screws and compared it with 2 mm AO miniplates and mini-screws made from titanium. Light microscopy evaluation showed that the PLLA/PGA copolymer system experienced its highest mechanical stress at the transition from screw head to screw shaft. Nevertheless, the fragments fixed with the copolymers were on the whole only slightly less stable than those fixed with the titanium system. The foreign body reaction solely due to co-polymer degradation was not severe, considering the fibrous tissue response that was found associated with the titanium components. The study does show that the copolymer investigated is adequate for clinical use as a biodegradable osteosynthesis material, at least in low stress bearing areas.
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