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  • Title: Biochemical markers of bone turnover during hormone replacement therapy.
    Author: Masahashi T, Negoro Y, Kuroki T, Asai M, Noguchi M, Nakanishi M.
    Journal: Int J Gynaecol Obstet; 1999 Feb; 64(2):163-6. PubMed ID: 10189026.
    Abstract:
    OBJECTIVE: To assess the clinical usefulness of bone turnover markers, including serum osteocalcin (OC), urinary pyridinoline (Pyr) and deoxypyridinoline (D-Pyr), in monitoring and predicting bone response to hormone replacement therapy (HRT). METHOD: The relationships between baseline levels or changes in markers and change in lumbar bone mineral density were examined in 21 surgically-induced postmenopausal women. RESULTS: Levels of OC, Pyr and D-Pyr in the estrogen effective group (responders) significantly decreased during HRT and baseline levels of Pyr and D-Pyr in responders were significantly higher than those in premenopausal women. CONCLUSION: Bone turnover markers were useful in monitoring the bone effect of HRT and baseline levels of markers reflect subsequent bone response to HRT.
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