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  • Title: The effects of the angiotensin II antagonist saralasin on blood pressure and plasma aldosterone in man in relation to the prevailing plasma angiotensin II concentration.
    Author: Brown JJ, Brown WC, Fraser R, Lever AF, Morton JJ, Robertson JI, Rosei EA, Trust PM.
    Journal: Prog Biochem Pharmacol; 1976; 12():230-41. PubMed ID: 1019166.
    Abstract:
    The effect of saralasin in lowering blood pressure and plasma aldosterone concentration in normal subjects, both sodium-replete and sodium-deplete, and in patients with various forms of hypertension, is closely related to the basal plasma angiotensin II concentration. These findings confirm and extend earlier studies of angiotensin II/arterial pressure and angiotensin II/aldosterone dose-response curves. They also emphasize the importance of the renin-angiotensin system in the control of aldosterone in sodium depletion and in renal hypertension.
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