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  • Title: Haemodynamic effects of Sar1-Ala8-angiotensin II in patients with renovascular hypertension.
    Author: Fagard R, Amery A, Ljnen P, Reybrouck T, Billiet L.
    Journal: Prog Biochem Pharmacol; 1976; 12():242-9. PubMed ID: 1019167.
    Abstract:
    Sar1-Ala8-angiotensin II was infused intravenously (10 mug/kg/min) in 14 patients with renovascular hypertension, including 11 with renal artery stenosis. Brachial artery pressure and heart rate remained unchanged in six patients who were on a daily sodium intake of 130 mEq. In 12 tests performed after sodium depletion, the decrease in mean arterial pressure ranged from 13 to 76 mm Hg and showed a significant correlation with the plasma renin concentration prevailing immediately before the infusion of the drug (r = 0.81; p less than 0.001). The hypotensive response was due to a drop in total peripheral resistance. Heart rate and cardiac output showed slight increases 10 min after the start of saralasin infusion.
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