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  • Title: Synthesis and reaction of cyanopyridone derivatives and their potential biological activities.
    Author: Salman AS.
    Journal: Pharmazie; 1999 Mar; 54(3):178-83. PubMed ID: 10192104.
    Abstract:
    4-Carboxy-3-cyano-6-biphenyl-pyrid-2-one (1) was prepared and then allowed to react with methyliodide, benzenesulphonyl chloride, phenylisothiocyanate, acetic anhydride, o-phenylenediamine, phenylmagnesium bromide and phosphorus pentasulphide affording the corresponding N-substituted pyrid-2-one 2-5, 4-(benzimidazol-2-yl)-pyrid-2-one 7, 2-hydroxy-2-phenyl-1,2-dihydro-pyridine 8 and 2-thiopyridone 9 derivatives, respectively. Treatment of 1 with dimethyl sulphate and phosphorus oxychloride to give 2-methoxy pyridine 12 and 2-chloro pyridine 13 derivatives. Reaction of 13 with amines and hydrazine hydrate afforded 14 and 15, respectively. The structural assignments of the new compounds were based on analytical, spectroscopic measurements and chemical reactions. Some of the obtained compounds showed interesting antibacterial and antifungal activities in vitro.
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