These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Diagnostic approaches to acute promyelocytic leukaemia.
    Author: O'Connor SJ, Evans PA, Morgan GJ.
    Journal: Leuk Lymphoma; 1999 Mar; 33(1-2):53-63. PubMed ID: 10194121.
    Abstract:
    Delivering the most effective clinical therapy in acute promyelocytic leukaemia (APL) is dependent on accurately making the diagnosis. The morphological diagnosis can be improved by detecting the presence of a specific chromosome translocation, the t(15;17)(q22;q21). This can be achieved using cytogenetics, RT-PCR, FISH and anti-PML monoclonal antibody. The optimal approach will be rapid, accurate and readily integrated into the routine haematology laboratory. Immunofluorescent detection of microparticulate PML protein fulfils these criteria, however, karyotyping will also detect the variant translocations and remains the 'gold-standard'.
    [Abstract] [Full Text] [Related] [New Search]