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  • Title: Morphometric examination of glomerulus and juxta glomerural system of rat kidney during prolonged restriction of motor activity.
    Author: Zorbas YG, Popov VK, Naexu KA, Kakurin VJ, Federenko YF.
    Journal: Physiol Chem Phys Med NMR; 1998; 30(2):229-37. PubMed ID: 10197360.
    Abstract:
    The aim of this study was to examine the structural changes of glomerular and juxta glomerular system (JGS) of the kidney of rats during prolonged restriction of motor activity (hypokinesia). The studies were performed during 90 days of hypokinesia (HK) on 144 male Wistar rats divided into two groups: Group one placed under ordinary vivarium conditions and serving as vivarium control rats (VCR) and Group two subjected to HK and serving as hypokinetic rats (HKR). For the simulation of the hypokinetic effect the HKR group was kept in small individual cages made of wood that restricted the movements of rats in all directions without hindering food and water intake. During a prehypokinetic period of 15 days and the hypokinetic period of 90 days, body weight and food intake were measured and morphometric examinations were done to measure the cortical and juxta medullary glomerulus on kidney sections from the VCR and HKR groups (eight rats from each group). Body weight and food intake decreased significantly in the HKR groups when compared with the VCR group. Kidney weight of rats increased, the superficial volume decreased and that of the juxta medullary glomerules increased, whereas juxta glomerular granularity indexes decreased significantly in the HKR group when compared with the VCR group. The measured parameters did not change significantly in the VCR group when compared with the baseline control values. It was concluded that prolonged exposure to HK induces a significant increase in the kidney weight and a relationship appeared between variations of the volume of cortical and juxta medullary glomerulus and the function of the juxtaglomerular apparatus.
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