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  • Title: Chorda tympani nerve transection, but not amiloride, increases the KCl taste detection threshold in rats.
    Author: Geran LC, Guagliardo NA, Spector AC.
    Journal: Behav Neurosci; 1999 Feb; 113(1):185-95. PubMed ID: 10197918.
    Abstract:
    Water-restricted rats were trained to press one lever after KCl presentation and the other lever after distilled water. Water reinforcement was given after each correct response, and a time-out followed each incorrect response. Rats were trained and tested on KCl stimuli of varying concentrations. Threshold was defined as the KCl concentration corresponding to 1/2 the maximum asymptote of performance for each rat. The geometric mean KCl detection threshold for all rats was 0.033 M KCl. Rats that had the chorda tympani nerve (CT) bilaterally transected showed an average increase in KCl threshold of approximately 0.60 log10 units, whereas sham-operated rats showed no change. Control rats retested with 100 microM amiloride added to all KCl concentrations and water displayed no change in threshold. These results suggest that although the CT contributes significantly to the rat's sensitivity to KCl, amiloride-sensitive taste transduction pathways do not.
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