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  • Title: A rapid feedback signal is not always necessary for termination of a drinking bout.
    Author: Houpt TR, Yang-Preyer H, Geyer J, Norris ML.
    Journal: Am J Physiol; 1999 Apr; 276(4):R1156-63. PubMed ID: 10198398.
    Abstract:
    When a pig is deprived of drinking water, a deficit of body water develops that is corrected when the pig drinks to satiation. If food is available during the deprivation, the stimulus to drinking is plasma hyperosmolality. Because of the delay in correction of plasma hyperosmolality as ingested water is slowly absorbed, it has been thought that a rapid inhibitory signal from the digestive tract is necessary to prevent overdrinking. This concept was tested by measuring changes in plasma osmolality before and during drinking after such deprivation and also after infusion of hypertonic saline. As drinking began, there was a rapid fall of plasma osmolality to levels insufficient to drive drinking by the time drinking ended. This fall of plasma hyperosmolality to subthreshold levels while the pig is drinking seems to make a rapid inhibitory control signal from the digestive tract unnecessary to terminate the drinking bout under these conditions.
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