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  • Title: Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation.
    Author: Fiorentini C, Gauthier M, Donelli G, Boquet P.
    Journal: Cell Death Differ; 1998 Sep; 5(9):720-8. PubMed ID: 10200530.
    Abstract:
    In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.
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