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  • Title: Retention of Tc-99m ECD in delayed SPECT of the brain.
    Author: Flores LG, Jinnouchi S, Nagamachi S, Ohnishi T, Futami S, Nakahara H, Shimoshinbara S, Ushinbana K, Tamura S.
    Journal: Ann Nucl Med; 1999 Feb; 13(1):1-4. PubMed ID: 10202941.
    Abstract:
    We determined the effect of retention on the changes in regional biodistribution of Tc-99m ECD in the brain. A total of 14 cases, 7 normal volunteers and 7 patients with various diagnoses but with very minimal radiologic findings or none were included in the study. SPECT images were taken at 30 min, 1, 2, 3, 4 and 6 hrs after an intravenous injection. Retention rates were calculated in various regions and were corrected according to the time decay of technetium. There was a tendency for the retention rate to increase up to three hours of imaging and then a decrease was noted in most regions of the brain. In the thalamus, increasing retention was noted. In conclusion, Tc-99m ECD retention in the different regions of the brain varies with time. These differences should always be considered when planning and interpreting SPECT quantitative studies.
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