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  • Title: [The role of prostaglandin E2 and its receptors in the regulation of osmotic permeability of the frog bladder epithelium].
    Author: Lavrova EA, Parnova RG.
    Journal: Ross Fiziol Zh Im I M Sechenova; 1998 Nov; 84(11):1287-92. PubMed ID: 10204174.
    Abstract:
    Arginine-vasotocin-induced enhancement of osmotic water flow was inhibited by PGE2, sulprostone, M&B 28767 and 17-phenyl-omega-trinor PGE2. The inhibitory action of these agents except M&B 28767 was more obvious when the osmotic water flow was activated by dibutyryl-cAMP. The findings suggest that, in the frog urinary bladder, the inhibitory effect of the PGE2 on arginine-vasotocin-induced water flow appears to be mediated via two receptor subtypes coupled with different secondary messengers. The inhibition-sensitive targets are localised both on pre- and post-cAMP steps of the hormonal signal transduction pathway.
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