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  • Title: The novel sarcomeric protein telethonin exhibits developmental and functional regulation.
    Author: Mason P, Bayol S, Loughna PT.
    Journal: Biochem Biophys Res Commun; 1999 Apr 21; 257(3):699-703. PubMed ID: 10208846.
    Abstract:
    We have isolated a cDNA clone from a mouse skeletal muscle library which is preferentially expressed in striated muscle and exhibits a high homology to human telethonin, a sarcomeric protein. The mouse telethonin transcript is developmentally regulated in both cardiac and skeletal muscle in vivo and is down-regulated in response to denervation. In the C2C12 muscle cell-line the mouse telethonin transcript exhibited a pattern of accumulation similar to that observed for a contractile protein and suggests a role in myofibrillar assembly.
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