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  • Title: Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
    Author: Luttrell LM, Daaka Y, Lefkowitz RJ.
    Journal: Curr Opin Cell Biol; 1999 Apr; 11(2):177-83. PubMed ID: 10209148.
    Abstract:
    Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.
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