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  • Title: Lactic acidosis caused by thiamine deficiency in a pregnant alcoholic patient.
    Author: Mukunda BN.
    Journal: Am J Med Sci; 1999 Apr; 317(4):261-2. PubMed ID: 10210363.
    Abstract:
    BACKGROUND: Metabolic acidosis from accumulation of lactic acid is a relatively common condition, whereas its causation by thiamine deficiency is not. METHODS: We studied a pregnant alcoholic patient who presented with hyperemesis and a high anion gap acidosis. RESULTS: Lactic acidosis and thiamine deficiency were confirmed. The patient's symptoms and acidosis resolved with thiamine administration. CONCLUSIONS: Lactic acidosis caused by thiamine deficiency must be suspected when pregnant patients at risk for thiamine deficiency present with a high anion gap acidosis. A large dose of thiamine must be administered immediately.
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