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  • Title: Interleukin-10 in combination with interferon-gamma and tumor necrosis factor-alpha enhances in vitro production of nitric oxide by murine resident paritoneal macrophage.
    Author: Zidek Z, Franková D.
    Journal: Eur Cytokine Netw; 1999 Mar; 10(1):25-32. PubMed ID: 10210769.
    Abstract:
    Resident peritoneal macrophages obtained from CBA/J mice were cultured in the presence of recombinant interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), and interleukin-10 (IL-10). IFN-gamma-stimulated nitric oxide (NO) formation, IL-10 substantially enhanced the production of NO generated by IFN-gamma + TNF-alpha, irrespective of the timing and dosing of any of the three cytokines. Increased levels of iNOS mRNA after the triple combination of IFN-gamma + TNF-alpha + IL-10 versus IFN-gamma + TNF-alpha suggest that the NO-enhancing effect is mediated, at the least partially, at the transcriptional level. Collectively, the present data support the view that IL-10 is not a general macrophage deactivating factor or a suppressor of gene expression.
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